As a sedative, muscle relaxant, diuretic, and as a remedy for nervousness and insomnia. Kava is a safe non-addictive; anxiety agents, kava has been shown to improve concentration, memory, and reaction time for people suffering from anxiety. All kavalactones are physiologically active, though it is the fat-soluble kavalactones derived from kava resin that have the greatest effect on the central nervous system. Kava also has a direct effect on muscle tension similar to tranquilizers. Kava is mildly narcotic and produces mild euphoric changes characterized by elevated mood, fluent and lively speech and increased sense of sound. Higher doses can lead to muscle weakness, visual impairment, dizziness and drying of the skin. Kava is the most relaxing botanical herb with exception of the opium poppy. Pharmacological studies show kava kava's active ingredients, kavalactones, produce physical and mental relaxation and a feeling of well being. It has also been used in the treatment of ailments of the genitourinary tract including vaginitis, gonorrhea and menstrual cramps. Kava is a diuretic and an anti-inflammatory, thus useful for gout, rheumatism, bronchial congestion, cystitis and prostatis. It is an effective local anesthetic and pain reliever when applied externally as a liniment. Several rhizome components and lactones have been isolated in the kava root. Of the fifteen lactones isolated from kava, there are six major lactones (kavalactones) known to provide psychoactive activity: kawain, methysticin, demethoxy-yangonin, dihydrokawain, dihydromethysticin, and yangonin. All kavalactones are physiologically active, though it is the fat-soluble kavalactones derived from kava resin that have the greatest effect on the central nervous system. Kava also has a direct effect on muscle tension similar to tranquilizers. The activity of the kava rhizome is related to several arylethylene pyrones similar in structure to myristicin, which is found in nutmeg.